GTCpFE - CAS 1588866-45-8

GTCpFE, a compound synthesized from Dimethyl fumarate (DMF) and Aspirin (ASA), inhibits IKKα/β in the NF-κB pathway, exhibiting anti-inflammatory activity by preventing p65 from entering the nucleus. It selectively inhibits cancer stem cell (CSC) activity by reducing the growth of mammospheres and the expression of the CD44+CD24- immune phenotype. Furthermore, GTCpFE targets breast cancer stem cells, crucial in aggressive cancer phenotypes that depend on NFκB and PGE2.

IκB/IKK, NF-κB

NF-κB

1588813

C22H20O8

412.39

C(OC1=CC=C(COC(/C=C/C(OCC)=O)=O)C=C1)(=O)C2=C(OC(C)=O)C=CC=C2

-20°C

Ice Packs

Small Compound