Gusacitinib HCl - CAS 2228989-14-6

Gusacitinib, also known as ASN-002 and EN-3351, is a potent dual inhibitor of SYK/JAK kinases. ASN002 showed strong antitumor activity in both hematological and solid tumor xenograft models. ASN002 strongly suppressed the SYK and JAK family kinase signaling pathways as measured in pLAT and pSTAT assays, respectively. When profiled in a panel of 178 cell lines, ASN002 showed strong anti-proliferative activity in many lymphoid/leukemia cell lines, including SU-DHL-6, SU-DHL-4, OCI-LY10, H929 and Pfeiffer.

JAK, Others, Syk

JAK/STAT signaling, Chromatin/Epigenetic, Angiogenesis, Others, Tyrosine Kinase/Adaptors, Stem Cells

2228969

C24H29ClN8O2

497

Cl.OC1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCC(CC#N)CC2)cc1

-20°C

Ice Packs

Small Compound