GW-841819X - CAS 146135-18-4

GW841819X is an analogue of (+) -JQ1 and a novel inhibitor of BET bromodomains. GW841819X displayed activity in vivo against NUT-midline carcinoma, multiple myeloma, mixed-lineage leukemia, and acute myeloid leukemia. Bromodomain and extra-terminal (BET) proteins belong to a class of proteins collectively called epigenetic readers". BET bromodomains have emerged as promising drug targets for treatment of cancers

Epigenetic Reader Domain, Others

Chromatin/Epigenetic, Others

146113

C25H21N5O2

423.47

CC=1N2C=3C(C(=NC(NC(OCC4=CC=CC=C4)=O)C2=NN1)C5=CC=CC=C5)=CC=CC3

-20°C

Ice Packs

Small Compound