GW274150 dihydrochloride - CAS 438542-17-7

GW274150 (dihydrochloride) is a potent and selective inhibitor of human and rat inducible nitric oxide synthase (iNOS), exhibiting oral activity and NADPH-dependence with an IC50 of 2.19 μM and Kd of 40 nM for human iNOS, and an ED50 of 1.15 μM for rat iNOS. It demonstrates reduced effectiveness against endothelial NOS (eNOS) and neuronal NOS (nNOS) in both species, and has shown protective effects in acute lung injury inflammation models [1] [2] [3].

NO Synthase

Immunology/Inflammation

438542-17-7

C8H19Cl2N3O2S

292.23

OC([C@@H](N)CCSCCNC(C)=N)=O.Cl.Cl

-20°C

Ice Packs

Small Compound