GW590735 sodium - CAS 343322-50-9

GW590735 is a potent and selective agonist of PPARα with an EC50 value of 4 nM for the expression a GAL4-responsive reporter gene and at least 500-fold selectivity versus PPARγ and PPARδ. GW590735 significantly increased HDL cholesterol, decreased LDL and VLDL cholesterol, and significantly reduced triglycerides. Maximal increases in HDL cholesterol were 37%, 53%, and 84% with fenofibrate, torcetrapib, and GW590735, respectively.

PPAR, Others

DNA Damage/DNA Repair, Others, Metabolism

343263

C23H20F3N2NaO4S

500.47

[O-]C(C(C)(C)OC(C=C1)=CC=C1CNC(C2=C(C)N=C(C3=CC=C(C=C3)C(F)(F)F)S2)=O)=O.[Na+]

-20°C

Ice Packs

Small Compound