GW779439X - CAS 551919-98-3

GW779439X is a pyrazolopyridazine compound that inhibits the S. aureus kinase Stk1 and Aurora kinase A (AURKA) . It restores the efficacy of β-lactam antibiotics against methicillin-resistant (MRSA) and methicillin-susceptible (MSSA) S. aureus, often re-sensitizing resistant strains. This antibacterial potentiation is achieved through the induction of apoptosis via caspase-3/7 pathway activation.

Apoptosis, Aurora Kinase, Antibacterial, CDK

Apoptosis, Chromatin/Epigenetic, Cell Cycle/Checkpoint, Microbiology/Virology

551818

0.9923

C22H21F3N8

454.45

CN1CCN(CC1)c1ccc(Nc2nccc(n2)-c2cnn3ncccc23)cc1C(F)(F)F

-20°C

Ice Packs

Small Compound