GYKI 52466 HCl - CAS 192065-56-8

GYKI 52466 is an allosteric AMPA receptor antagonist. It selectively inhibits AMPA-induced inward currents (IC50 = 7.5 μM) over NMDA- or GABA-induced inward currents in primary rat hippocampal neurons at 50 μM but also inhibits kainate-induced inward currents in the same cells (IC50 = 11 μM) .2 GYKI 52466 (10 μM) reduces the amplitude of spontaneous excitatory postsynaptic currents (EPSCs) in the same cells. It increases the latency to seizure onset and reduces mortality in a rat model of generalized tonic-clonic seizures induced by 4-aminopyridine (4-AP) when administered at doses of 25 and 50 mg/kg. GYKI 52466 (30 mg/kg) prevents neuronal damage in the CA1 region of the hippocampus in a rat model of global ischemia-reperfusion injury induced by four-vessel occlusion.

Others, iGluR

Others, Neuroscience, Membrane transporter/Ion channel

192001

C17H16ClN3O2

329.784

Cl.CC1=NN=C(c2ccc(N)cc2)c2cc3OCOc3cc2C1

-20°C

Ice Packs

Small Compound