GZ-11608 - CAS 2141974-01-6

GZ-11608, a selective and potent inhibitor of vesicular monoamine transporter-2 (VMAT2), presents a high affinity with a Ki value of 25 nM. It effectively reduces dopamine release induced by methamphetamine from isolated synaptic vesicles in brain dopaminergic neurons. GZ-11608 also demonstrates rapid penetration into the brain without exhibiting neurotoxicity, making it a valuable compound for researching methamphetamine use disorder [1].

Monoamine Transporter

Membrane transporter/Ion channel

2141974-01-6

C19H25NO

283.41

C([C@@H](NCCCC1=CC=C(OC)C=C1)C)C2=CC=CC=C2

-20°C

Ice Packs

Small Compound