GZD856 formic - CAS 2804039-78-7

GZD856 formic is a potent, orally active inhibitor of PDGFRα/β and Bcr-Abl T315I, demonstrating IC50 values of 68.6 nM and 136.6 nM for PDGFRα/β, respectively, and 19.9 nM and 15.4 nM for native Bcr-Abl and the T315I mutant, respectively. This compound exhibits significant antitumor activity.

Apoptosis, PDGFR, Others, Bcr-Abl

Angiogenesis, Others, Apoptosis, Tyrosine Kinase/Adaptors, Cytoskeletal Signaling

2803954

C30H29F3N6O3

578.58

C(O)=O.C(C1=C(C(F)(F)F)C=C(NC(=O)C2=CC(C#CC3=CN4C(N=C3)=CC=N4)=C(C)C=C2)C=C1)N5CCN(C)CC5

-20°C

Ice Packs

Small Compound