H-L-Phe (4-NH-Poc) -OH hydrochloride - CAS 2737202-66-1

H-L-Phe (4-NH-Poc) -OH (hydrochloride) is a chemical reagent utilized in the modification of phenylalanine or tyrosine analogues in protein and peptide biosynthesis. It contains an alkyne group, facilitating its role in copper-catalyzed azide-alkyne cycloaddition (CuAAC) with molecules that have azide groups. Commonly abbreviated as Poc or Pryoc, this compound acts as both a conventional click conjugation alkyne component and can be combined with tetrazine linkers in copper-free Diels-Alder type click reactions. Additionally, H-L-Phe (4-NH-Poc) -OH serves as a specialized protective group for amines, hydroxyl, and ester groups. Stable under neat trifluoroacetic acid (TFA), degradation occurs at room temperature using TFA:DCM with Co2 (CO) 8. Deprotection involving other transition metals such as palladium has also been reported.

ADC Linker

Antibody-drug Conjugate/ADC Related

2737202-66-1

C13H15ClN2O4

298.72

C([C@@H](C(O)=O)N)C1=CC=C(NC(OCC#C)=O)C=C1.Cl

-20°C

Ice Packs

Small Compound