H3B-6545 - CAS 2052130-80-8

H3B-6545 is a selective estrogen receptor covalent antagonist (SERCA) that is orally available. As a novel class of ERα antagonists, H3B-6545 is used in the study of metastatic breast cancers, such as estrogen receptor-positive (ER), human epidermal growth factor receptor 2-negative (HER2-) breast cancer.

Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Endocrinology/Hormones

2052042

C30H29F4N5O2

567.58

C(=C(\CC(F)(F)F)/C1=CC=CC=C1)(\C=2C=C3C(=CC2)NN=C3F)/C=4C=CC(OCCNC/C=C/C(N(C)C)=O)=NC4

-20°C

Ice Packs

Small Compound