H3B-968 - CAS 2912294-90-5

H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) with an IC50 of approximately 10 nM, targeting its helicase, ATPase, and exonuclease activities. While WRN is known for its synthetic lethal activity in cancer studies, H3B-968 specifically inhibits WRN's helicase function through competitive ATP antagonism [1].

DNA/RNA Synthesis

DNA Damage/DNA Repair, Cell Cycle/Checkpoint

2912199

C22H18F6N4O4S

548.46

S(NCC(NC1=CC=C(CC)C=C1)=O)(=O)(=O)C=2N=C(C=C(C(F)(F)F)N2)C3=CC=C(OC(F)(F)F)C=C3

-20°C

Ice Packs

Small Compound