H3R antagonist 6 - CAS 2183338-59-0

H3R antagonist 6 (Compounds 3) (H3-2406) is a histamine receptor 3 (H3R) antagonist with an IC50 of 5.6 nM. The 18F-labeled version exhibits high radiochemical yield, molar activity, and moderate brain uptake, although it shows off-target binding with the Sigma-1 receptor. It serves as a radioligand for positron emission tomography (PET) imaging in the study of central nervous system (CNS) diseases.

Sigma receptor, Histamine Receptor

Neuroscience, Immunology/Inflammation, GPCR/G Protein

2183279

C19H25FN2O

316.41

O=C(N1CCN(CC1)C2CCCC2)C3CC3C4=CC=C(F)C=C4

-20°C

Ice Packs

Small Compound