HA-14-1 - CAS 927635-64-1

HA-14-1, a small molecule, binds the surface pocket of Bcl-2 proteins (IC50= ~ 9 μM), including Bcl-xl and Bcl-W, and disrupts their interaction with the Bak peptide. This action induces apoptosis by activating Apaf-1 and caspase-9 and -3. Additionally, HA-14-1 effectively induces apoptosis in human acute myeloid leukemia (HL-60) cells, with a 50 μM concentration resulting in a 90% loss of cell viability.

Others, Bcl-2 Family

Apoptosis, Others

927635-64-1

C17H17BrN2O5

409.2

C(C(OCC)=O)(C#N)C1C=2C(OC(N)=C1C(OCC)=O)=CC=C(Br)C2

-20°C

Ice Packs

Small Compound