HAChE/hBACE-1-IN-4 - CAS 229476-71-5

Compound AK-2, also known as hAChE/hBACE-1-IN-4, is a quinazoline derivative that demonstrates significant inhibitory activity against the enzymes hAChE and hBACE-1 (hAChE, IC 50 = 0.283 μM; hBACE-1, IC 50 = 0.231 μM) . This compound also shows potential in inhibiting Aβ aggregation and possesses characteristics such as non-neurotoxicity, blood-brain barrier permeability, and oral activity, making it a valuable agent for research in Alzheimer's disease [1].

Cholinesterase (ChE), Beta Amyloid

Neuroscience

229476-71-5

C21H24N4O2

364.44

O(C)C1=CC=2C(=NC=NC2C=C1OC)N3CCN(CC4=CC=CC=C4)CC3

-20°C

Ice Packs

Small Compound