HAChE-IN-10 - CAS 3058182-98-9

HAChE-IN-10 (Compound ET11) is an inhibitor of human acetylcholinesterase (AChE) with an IC50 of 6.34 nM. This compound is capable of scavenging free radicals and exhibits antioxidant activity. Additionally, hAChE-IN-10 demonstrates metal-chelating properties, inhibiting Cu2+-induced Aβ1-42 aggregation, reducing amyloid plaque formation, and offering neuroprotective effects. It also ameliorates cognitive impairment in mice induced by Scopolamine.

Cholinesterase (ChE), Beta Amyloid

Neuroscience

3058075

C25H24ClFN6O2

494.948

O=C(NCCCNC=1C=2C=CC(Cl)=CC2N=C3C1CCCC3)C4=NN(C(O)=C4)C5=NC=C(F)C=C5

-20°C

Ice Packs

Small Compound