Halofuginone hydrobromide - CAS 64924-67-0

Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibroproliferative diseases.

TGF-beta/Smad, DNA/RNA Synthesis, Sodium Channel, Calcium Channel, Parasite

DNA Damage/DNA Repair, Membrane transporter/Ion channel, Microbiology/Virology, Stem Cells, Metabolism, Cell Cycle/Checkpoint

64857

0.9973

C16H17BrClN3O3.HBr

495.59

Br.O[C@H]1CCCN[C@@H]1CC(=O)Cn1cnc2cc(Br)c(Cl)cc2c1=O

-20°C

Ice Packs

Natural Product