Halofuginone hydrochloride - CAS 1217623-74-9

Halofuginone hydrochloride (RU-19110), a derivative of Febrifugine, functions as a competitive inhibitor of prolyl-tRNA synthetase, displaying a Ki value of 18.3 nM. This compound effectively inhibits type-I collagen synthesis, providing therapeutic benefits in osteoarthritis (OA) by impeding TGF-β signaling. Additionally, it serves as a potent pulmonary vasodilator, mainly through the activation of Kv channels and the inhibition of various calcium channels including voltage-gated, receptor-operated, and store-operated ones. Beyond its vascular effects, Halofuginone hydrochloride exhibits a broad spectrum of biological activities, including anti-malarial, anti-inflammatory, anti-cancer, and anti-fibrotic properties, supported by multiple studies.

Sodium Channel, DNA/RNA Synthesis, Others, Parasite, Calcium Channel, TGF-beta/Smad

Membrane transporter/Ion channel, Others, Metabolism, Stem Cells, Microbiology/Virology, Cell Cycle/Checkpoint, DNA Damage/DNA Repair

1217623-74-9

C16H18BrCl2N3O3

451.14

Cl.OC1CCCN[C@H]1CC(=O)Cn1cnc2cc(Br)c(Cl)cc2c1=O

-20°C

Ice Packs

Small Compound