HALOFUGINONE LACTATE - CAS 82186-71-8

HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.Halofuginone inhibits prolyl-tRNA synthetase in an ATP-dependent manner with a Ki of 18.3 nM. Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity

TGF-beta/Smad, Sodium Channel, DNA/RNA Synthesis, Calcium Channel, Parasite

Membrane transporter/Ion channel, DNA Damage/DNA Repair, Metabolism, Cell Cycle/Checkpoint, Microbiology/Virology, Stem Cells

82107

0.9996

C19H23BrClN3O6

504.8

CC(O)C(O)=O.O=C1N(CC(C[C@@H]2NCCC[C@H]2O)=O)C=NC3=C1C=C(Cl)C(Br)=C3

-20°C

Ice Packs

Small Compound