HBI-2375 - CAS 2982574-79-6

HBI-2375 (HYBI-084) is a selective inhibitor that penetrates the blood-brain barrier and is orally active, targeting the MLL1-WDR5 interaction. It inhibits WDR5 with an IC50 of 4.48 nM and demonstrates antiproliferative activity in MV4;11 leukemia cells with an IC50 of 3.17 μM. Furthermore, HBI-2375 disrupts histone methyltransferase activity in cancer cells and is useful for researching leukemia, glioma, and glioblastoma.

Histone Methyltransferase, JAK

Chromatin/Epigenetic, Angiogenesis, Tyrosine Kinase/Adaptors, Stem Cells, JAK/STAT signaling

2982489

C29H36ClF2N9O2

616.11

N(C(=O)C1=C(Cl)C(C)=C(F)C(N)=C1)C2=C(C=C(F)C(=C2)N3C=C(C(=O)N4CCN(C)CC4)N=N3)N5C[C@@H](C)N(C)[C@@H](C)C5

-20°C

Ice Packs

Small Compound