HC Toxin - CAS 83209-65-8

HC Toxin is a cell-permeable, reversible inhibitor of histone deacetylases (HDACs) (IC50 = 30 nM) . Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells. HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize.

Apoptosis, Others, HDAC

Others, Apoptosis, Chromatin/Epigenetic, DNA Damage/DNA Repair

83209-65-8

C21H32N4O6

436.509

C[C@H]1NC(=O)[C@H](CCCCCC(=O)[C@@H]2CO2)NC(=O)[C@H]2CCCN2C(=O)[C@H](C)NC1=O

-20°C

Ice Packs

Small Compound