HCAR2 agonist 1 - CAS 1066676-21-8

HCAR2 agonist 1 (Compound 9n), a G i protein-biased allosteric modulator of HCAR2, activates the G i protein signaling pathway and exhibits anti-inflammatory properties by reducing mRNA levels of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, and MCP-1) . Additionally, it potentiates the anti-inflammatory effects of orthosteric agonists in a mouse model of colitis [1].

Others, HCAR

GPCR/G Protein, Others

1066676-21-8

C26H28N4O2

428.53

CC=1N2C(=C(C=N2)C3=CC=C(C(C)C)C=C3)N=CC1C(N[C@@H](COC4=CC=CC=C4)C)=O

-20°C

Ice Packs

Small Compound