HD-TAC7 - CAS 2978763-95-8

HD-TAC7, a potent PROTAC HDAC degrader, exhibits IC50 values of 3.6 μM, 4.2 μM, and 1.1 μM for HDAC1, HDAC2, and HDAC3, respectively. It effectively decreases NF-κB p65 in RAW 264.7 macrophages and is utilized in research targeting inflammatory diseases such as asthma and chronic obstructive pulmonary disease (COPD) [1].

PROTACs, HDAC

DNA Damage/DNA Repair, PROTAC, Chromatin/Epigenetic

2978660

C33H32FN7O7

657.65

O=C(NC1=CC=C(F)C=C1N)C2=CC=C(C=C2)NC(=O)CCCCNC(=O)CNC3=CC=CC=4C(=O)N(C(=O)C34)C5C(=O)NC(=O)CC5

-20°C

Ice Packs

PROTAC