HDAC-IN-27 dihydrochloride - CAS 3069831-25-7

HDAC-IN-27 dihydrochloride (Compound 11h) is a potent, orally active, HDACI class-selective inhibitor, with IC50 values ranging from 0.43 to 3.01 nM for HDAC1-3. This compound exhibits both in vivo and in vitro anticancer activity. HDAC-IN-27 shows significant antiproliferative effects against acute myeloid leukemia (AML) cell lines by inducing apoptosis and histone acetylation (AcHH3 and AcHH4) . It is useful for research on acute myeloid leukemia (AML) .

HDAC, Apoptosis

DNA Damage/DNA Repair, Chromatin/Epigenetic, Apoptosis

3069799

C20H24Cl2N4O2

423.336

O=C(C1=CC=C(CNC(C2=CC3=C(N2)C=CC=C3)=O)C=C1)NNCCC.Cl.Cl

-20°C

Ice Packs

Small Compound