HDAC-IN-43 - CAS 1809163-24-3

HDAC-IN-43 is a potent HDAC 1/3/6 inhibitor with IC50 values of 82 nM for HDAC 1, 45 nM for HDAC 3, and 24 nM for HDAC 6, and a weak PI3K/mTOR inhibitor with IC50 values of 3.6 μM for PI3K and 3.7 μM for mTOR, exhibiting a broad-spectrum anti-proliferative effect.

Others, PI3K, mTOR, HDAC

PI3K/Akt/mTOR signaling, Others, Chromatin/Epigenetic, DNA Damage/DNA Repair

1809136

C22H28N6O4

440.5

C(C)(C)N1C=2C(=C(N=C(N2)N3CCOCC3)C4=CC(OCCCC(NO)=O)=CC=C4)N=C1

-20°C

Ice Packs

Small Compound