HDAC-IN-45 - CAS 2421122-61-2

HDAC-IN -45, a small molecule HDAC inhibitor, was able to form hydrogen bonds with Y303 residues and exhibited anticancer effects. HDAC-IN-45 significantly inhibited HDAC1, HDAC2 and HDAC3 subtypes with their IC50 values of 0.108, 0.585 and 0.563 μM, respectively.

Others, HDAC

Others, DNA Damage/DNA Repair, Chromatin/Epigenetic

2421059

C25H20ClFN8O

502.93

C(N1C=2C(=C(NC3=CC(Cl)=C(F)C=C3)N=C(N)N2)N=C1)C4=CC=C(C(NC5=C(N)C=CC=C5)=O)C=C4

-20°C

Ice Packs

Small Compound