HDAC-IN-46 - CAS 2562386-85-8

HDAC-IN-46 (compound 12c) is a potent inhibitor of HDAC, targeting HDAC1 (IC50: 0.21 μM) and HDAC6 (IC50: 0.021 μM) . It upregulates p-p38, downregulates Bcl-xL and cyclin D1 in MDA-MB-231 cells, blocks the cell cycle in the G2 phase, and induces apoptosis, making it useful for triple negative breast cancer (TNBC) studies.

Apoptosis, Others, HDAC

Chromatin/Epigenetic, Apoptosis, Others, DNA Damage/DNA Repair

2562293

C22H30N8O2

438.53

C(C)C=1C(C2=CC=C(C=C2)C3=CN(CCCCCCCC(NO)=O)N=N3)=C(N)N=C(N)N1

-20°C

Ice Packs

Small Compound