HDAC-IN-56 - CAS 2814571-89-4

HDAC-IN-56 ((S) -17b), an orally active inhibitor of class I histone deacetylase (HDAC), exhibits inhibitory constants (IC 50) of 56.0 ± 6.0 nM for HDAC1, 90.0 ± 5.9 nM for HDAC2, 422.2 ± 105.1 nM for HDAC3, and greater than 10,000 nM for HDAC4-11. This compound displays robust antitumor activity [1], marked by its ability to significantly elevate intracellular acetylhistone H3 and P21 levels, while also inducing G1 cell cycle arrest and apoptosis effectively.

HDAC

DNA Damage/DNA Repair, Chromatin/Epigenetic

2814571-89-4

C28H28FN5O2

485.55

[C@@H](C)(N1N=C(C=CC1=O)C2=CC=C(CN(C)C)C=C2)C3=CC=C(C(NC4=C(N)C=C(F)C=C4)=O)C=C3

-20°C

Ice Packs

Small Compound