HDAC-IN-63 - CAS 2920046-95-1

HDAC-IN-63 (Compound 63) is a dual FLT3/HDAC inhibitor with IC50 values of 0.844 nM for FLT3 and 30.0 nM for HDAC1. It effectively suppresses MV4-11 cell proliferation (IC50 of 92 nM), induces apoptosis, and arrests the cell cycle in MV4-11 cells. This compound is applied in acute myeloid leukemia (AML) research [1].

FLT, Apoptosis, Others, HDAC

DNA Damage/DNA Repair, Apoptosis, Others, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic, Angiogenesis

2919950

C25H26Cl2N6O3

529.42

C(N1C=2C(N=C1)=CC=C(C2)C3=CC(NC(CCCCCCC(NO)=O)=O)=NN3)C4=C(Cl)C=CC=C4Cl

-20°C

Ice Packs

Small Compound