HDAC/Top-IN-1 - CAS 2411379-14-9

HDAC/Top-IN-1 is a broad-spectrum, orally active dual HDAC/Top inhibitor that acts on HDAC1 (IC50: 0.036 μM), HDAC2 (IC50: 0.14 μM), HDAC3 (IC50: 0.059 μM), HDAC6 (IC50: 0.089 μM) and HDAC8 (IC50: 9.8 μM) . HDAC/Top-IN-1 was able to block HEL cells in S-phase and effectively induce apoptosis.

Others, Topoisomerase, HDAC

DNA Damage/DNA Repair, Chromatin/Epigenetic, Others

2411356

C29H25FN4O4

512.53

CN1C2(C3=C(C=4C(N3)=CC=C(OCC5=CC=C(/C=C/C(NO)=O)C=C5)C4)CCN2C(=O)C=6C1=CC=C(F)C6)[H]

-20°C

Ice Packs

Small Compound