HDAC1/2 and CDK2-IN-1 - CAS 2418559-01-8

HDAC1/2 and CDK2-IN-1 (compound 14d) are potent inhibitors of HDAC1, HDAC2, and CDK2 with IC50 values of 70.7, 23.1, and 0.80 μM, respectively. HDAC1/2 and CDK2-IN-1 can block the cell cycle and induce apoptosis, demonstrating good anti-tumor effects in vivo.

Apoptosis, Others, HDAC, CDK

Chromatin/Epigenetic, Apoptosis, Others, Cell Cycle/Checkpoint, DNA Damage/DNA Repair

2418559-01-8

C26H22ClN7O

483.95

C(N1C=2C(=C(NC3=CC=C(C)C=C3)N=C(Cl)N2)N=C1)C4=CC=C(C(NC5=C(N)C=CC=C5)=O)C=C4

-20°C

Ice Packs

Small Compound