HDAC1/6-IN-3 - CAS 3038691-85-6

HDAC1/6-IN-3 is an effective HDAC inhibitor with significant inhibitory effects on HDAC1 (IC50= 1.1 nM) and HDAC6 (IC50= 2.7 nM) . In HepG2 cells, it causes cell cycle arrest at the G0/G1 phase and induces apoptosis and pyroptosis. Furthermore, HDAC1/6-IN-3 demonstrates notable antitumor activity in HepG2 tumor xenograft models. This compound is applicable for cancer research, including studies on liver, lung, colon, and breast cancers.

Apoptosis, Pyroptosis, HDAC

DNA Damage/DNA Repair, Apoptosis, Immunology/Inflammation, Chromatin/Epigenetic

3038600

C24H27N3O4S

453.55

O=C(NO)CCCCCC(=O)N(C1=CC=C(OC)C=C1)CC=2N=C(SC2)C=3C=CC=CC3

-20°C

Ice Packs

Small Compound