HDAC11-IN-3 - CAS 2989934-63-4

HDAC11-IN-3 (Compound A9) is a selective inhibitor of HDAC11, exhibiting an IC50 value of 4.1 nM. It demonstrates inhibitory effects on U937 and OCI-AML2 acute myeloid leukemia (AML) cell lines with an IC50 of 10 μM. This compound shows significant anti-AML activity by inducing apoptosis, cell cycle arrest, and differentiation. HDAC11-IN-3 upregulates the iron transport proteins transferrin (TF) and transferrin receptor (TFRC), and activates the p62-Keap1-Nrf2-HMOX1 pathway, which collectively increases intracellular iron levels and induces ferroptosis in AML cells. HDAC11-IN-3 can be utilized for AML research either alone or in combination with Cytarabine.

HDAC, Apoptosis, Ferroptosis

DNA Damage/DNA Repair, Chromatin/Epigenetic, Apoptosis

2989867

C18H11F3N2O2

344.29

O=C(NO)C=1C=CC=C2NC(C#CC3=CC=CC(=C3)C(F)(F)F)=CC21

-20°C

Ice Packs

Small Compound