HDAC3-IN-4 - CAS 2988762-46-3

HDAC3-IN-4 is a selective and orally active inhibitor of HDAC3, boasting an IC50 of 89 nM. It induces the degradation of PD-L1 by modulating cathepsin B (CTSB) in lysosomes, with a DC50 of 5.7 μM. Compared to HDAC1, HDAC6, HDAC7, and HDAC8, HDAC3-IN-4 demonstrates superior selectivity for HDAC3.

2988762-46-3

C22H25N5O2S

423.53

O=C(NCC1=CC=C(C=C1)C(=O)NNCCC)C2=NC=C(S2)CNC=3C=CC=CC3

-20°C

Ice Packs

Small Compound