HDAC3 Inhibitor - CAS 2044701-99-5

HDAC3 inhibitor is an allosteric inhibitor of histone deacetylase 3 (HDAC3; Ki = 0.16 nM) . It is selective for HDAC3 over HDAC1 and HDAC2 (IC50s = 0.95, 11.81, and 95.45 nM, respectively, using recombinant HDACs) . In addition, it is selective for acute myeloid, monocytic, and lymphoblastic leukemia cell lines (EC50s = 36.37, 76.64, and 151.7 nM, respectively) over chronic myeloid, acute promyelocytic, and acute lymphoblastic cells (EC50s = 2,160, >10,000, and >10,000 nM, respectively) .

HDAC, Others

Others, Chromatin/Epigenetic, DNA Damage/DNA Repair

2044597

C20H23N3O2

337.42

C(NNCCC)(=O)C1=CC=C(CNC(/C=C/C2=CC=CC=C2)=O)C=C1

-20°C

Ice Packs

Small Compound