HDAC6 degrader-1 - CAS 2439058-23-6

HDAC6 degrader-1, a proteolysis-targeting chimeric molecule (PROTAC), incorporates the selective HDAC6 inhibitor Nexturastat A (Nex A) for HDAC6 binding, a linker, and an E3 ligase recruiting ligand. This compound effectively induces HDAC6 degradation, displays superior selectivity over other HDAC isoforms, and efficiently inhibits cell proliferation [1].

PROTACs

PROTAC

2439029

C40H45N9O9

795.84

O=C(NO)C1=CC=C(C=C1)CN(C(=O)NC=2C=CC=CC2)CCCCC=3N=NN(C3)CCOCCOCCNC4=CC=CC=5C(=O)N(C(=O)C45)C6C(=O)NC(=O)CC6

-20°C

Ice Packs

PROTAC