HDAC6/HSP90-IN-1 - CAS 2411955-43-4

HDAC6/HSP90-IN-1 is a potent and selective dual inhibitor of HDAC6 (IC50: 4.3 nM) and HSP90 (IC50: 46.8 nM) .HDAC6/HSP90-IN-1 downregulates PD-L1 expression in INF-γ-treated H1975 lung cancer cells.HDAC6/HSP90-IN-1 exhibits tumor growth inhibition in H1975 xenograft mice.HDAC6/HSP90-IN-1 is a potent and selective dual inhibitor of HDAC6 (IC50: 4.3 nM) and HSP90 (IC50: 46.8 nM) . 1 exhibited tumor growth inhibition in H1975 xenograft mice.

HDAC, Others, HSP

Cytoskeletal Signaling, Others, DNA Damage/DNA Repair, Metabolism, Chromatin/Epigenetic

2411908

C28H37N3O6

511.61

C(=O)(N1CC=2C(C1)=CC(NC(CCCCCCCCC(NO)=O)=O)=CC2)C3=CC(C(C)C)=C(O)C=C3O

-20°C

Ice Packs

Small Compound