HDAC6-IN-33 - CAS 2444302-23-0

HDAC6-IN-33 (compound 6), an irreversible and selective HDAC6 inhibitor, demonstrates a potency with an IC 50 of 193 nM and lacks activity against HDAC1-4. This compound adheres to HDAC6 through a two-step slow-binding mechanism, establishing it as a tight-binding inhibitor [1].

HDAC

Chromatin/Epigenetic, DNA Damage/DNA Repair

2444302-23-0

C14H11F2N5O

303.27

C(F)(F)C=1OC(=NN1)C=2C=NC(NCC3=CC=CC=C3)=NC2

-20°C

Ice Packs

Small Compound