HDAC6-IN-34 - CAS 1432508-73-0

HDAC6-IN-34 (compound 21), an orally active, selective HDAC6 inhibitor, exhibits an IC50 of 18 nM. It enhances tubulin acetylation levels without impacting histone acetylation in cutaneous T-cell lymphoma cells and suppresses TNF-α secretion in LPS-stimulated macrophage cells. Furthermore, HDAC6-IN-34 demonstrates outstanding anti-arthritic efficacy in rats [1].

HDAC

DNA Damage/DNA Repair, Chromatin/Epigenetic

1432508-73-0

C18H18F3N3O3

381.35

C(N1C2=C(C(C(F)(F)F)=N1)C(=O)CC(C)(C)C2)C3=CC=C(C(NO)=O)C=C3

-20°C

Ice Packs

Small Compound