HDAC6-IN-37 - CAS 2986486-82-0

HDAC6-IN-37 (compound W5), an HDAC6 inhibitor, exhibits neuroprotective properties. It effectively restores the morphology of hippocampal neurons and diminishes the expression of Aβ, Tau, and p-Tau proteins in the hippocampus of AD rats. Additionally, it prevents the formation of senile plaques and neurofibrillary tangles. Consequently, HDAC6-IN-37 ameliorates the symptoms in the Aβ/Cu 2+ -induced AD rat model, regulates oxidative stress, and restores balance to neurotransmitter levels in brain tissue [1].

HDAC

DNA Damage/DNA Repair, Chromatin/Epigenetic

2986486-82-0

C19H16ClN3O2S

385.87

C(N1C=2C(SC=3C1=CC=CC3)=CC=CC2)C4=CC=C(C(NO)=O)C=N4.Cl

-20°C

Ice Packs

Small Compound