HDAC6-IN-45 - CAS 3048532-05-1

HDAC6-IN-45 (Compound 15) is a selective inhibitor of HDAC6, with an IC50 of 15.2 nM. It exerts neurotrophic effects by upregulating GAP43 and Beta-3 Tubulin markers. Additionally, HDAC6-IN-45 activates the Nrf2 signaling pathway, reduces H2O2-induced ROS production, and inhibits apoptosis in PC12 cells. In zebrafish models of Alzheimer's disease, it demonstrates neuroprotective properties. Moreover, HDAC6-IN-45 exhibits antioxidant activity and has favorable blood-brain barrier (BBB) permeability.

HDAC, Nrf2, Reactive Oxygen Species, Apoptosis

Apoptosis, DNA Damage/DNA Repair, Chromatin/Epigenetic, Immunology/Inflammation, Metabolism, NF-κB

3048532-05-1

C23H24FN3O2

393.45

O=C(NO)C1=CC=C(C=C1)CN2CC3=C(C=4C=C(F)C=CC4N3CC5CC5)CC2

-20°C

Ice Packs

Small Compound