HDAC8-IN-12 - CAS 3028095-13-5

HDAC8-IN-12 (compound 5k), a non-hydroxamic acid derivative, serves as a selective HDAC8 inhibitor with an IC 50 of 0.12 nM and demonstrates potent efficacy against breast cancer. This compound enhances anti-tumor immunity by activating T cells, elevating M1 macrophage levels, and reducing M2 macrophage proportions. In an orthotopic mouse model of breast cancer, HDAC8-IN-12, administered at 50 mg/kg, effectively suppresses tumor growth.

HDAC

Chromatin/Epigenetic, DNA Damage/DNA Repair

3028077

C16H17N3O5

331.32

O=C(C=CC1=CC=C(C=C1OC)C=C2C(=O)NCC(=O)N2C)NO

-20°C

Ice Packs

Small Compound