HDGFRP2/PSIP1-IN-1 - CAS 166196-54-9

Compound BPP (HDGFRP2/PSIP1-IN-1) is a dual inhibitor targeting the PWWP domains of Hepatoma-derived Growth Factor Related Protein 2 (HDGFRP2) and its homologue PSIP1. This compound effectively hinders the occurrence and progression of Diffuse Intrinsic Pontine Glioma (DIPG) . It demonstrates binding affinity with a Kd value of 7 μM for HDGFRP2, indicative of its efficient ligand efficacy at 0.47. Additionally, Compound BPP exhibits a Kd value of 27 μM when binding to the PSIP1 PWWP domain, and a Kd value of 14 μM against HDGFRP3, confirming its potency as an inhibitor within the HDGFRP2 PWWP subfamily.

Others, DNA/RNA Synthesis

Others, Cell Cycle/Checkpoint, DNA Damage/DNA Repair

166133

C8H6BrN3

224.06

BrC1=CNN=C1C=2C=CN=CC2

-20°C

Ice Packs

Small Compound