Hdm2 E3 ligase inhibitor 1 - CAS 414905-09-2

Hdm2 E3ligaseinhibitor 1 (Compound 1) is a reversible inhibitor of Hdm2-mediated p53 protein ubiquitination, with an IC50 of 12.7 μM. It binds to Hdm2, blocking the transfer of ubiquitin catalyzed by Hdm2 from pre-linked Ub-Ubc4 to p53, thereby inhibiting p53 ubiquitination, stabilizing p53 protein in tumor cells, and exerting antitumor activity.

MDM-2/p53, E1/E2/E3 Enzyme

Apoptosis, Ubiquitination

414905-09-2

C10H8F6N2O3S

350.24

O=C(NC1=CC=C(C=C1)S(=O)(=O)N)C(C(F)(F)F)C(F)(F)F

-20°C

Ice Packs

Small Compound