Hederacolchiside A1 - CAS 106577-39-3

Hederacolchiside A1 (Raddeanoside R13) shows anti-leishmanial activity, it exhibits a strong antiproliferative activity on all stages of development of the parasite by altering membrane integrity and potential. Hederacolchiside A1 shows antiproliferation activities in three cancer cell lines with the IC50 value of 2.4 uM, it exhibits a preferential cytotoxicity on a pigmented melanoma cell line. It suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway.

MEK, ERK, Parasite, mTOR, Akt, Apoptosis, PI3K

PI3K/Akt/mTOR signaling, Cytoskeletal Signaling, MAPK, Apoptosis, Microbiology/Virology

106535

0.9992

C47H76O16

897.1

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-20°C

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Natural Product