Hedgehog Antagonist VIII - CAS 330796-24-2

Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers, including glioblastoma, for which the Gli proteins are named. Hh antagonist VIII is a cell-permeable quinazolinyl-urea compound that has been shown to inhibit Gli transcription activity with an IC50 value of 70 nM.

Others, Hedgehog/Smoothened

Stem Cells, Others, GPCR/G Protein

330796-24-2

C23H15ClF4N4O2

490.84

FC1=CC=C(C=C1)N1C(=O)C2=C(C=CC=C2)N=C1CNC(=O)NC1=CC=C(Cl)C(=C1)C(F)(F)F

-20°C

Ice Packs

Small Compound