Heliquinomycin - CAS 178182-49-5

Heliquinomycin is a bacterial metabolite originally isolated fromStreptomycesthat has diverse biological activities.1It is active against a variety of Gram-positive bacteria, including strains ofB. anthracis, B. subtilis, and methicillin-sensitive or -resistantS. aureus (MICs = <0.05-0.39 μg/ml) . Heliquinomycin inhibits the activity of DNA helicase with a Kivalue of 6.8 μM. It reduces the growth of L1210 leukemia, B16 melanoma, and FS-3 fibrosarcoma cells (IC50s = 0.97, 0.89, and 0.83 μg/ml, respectively) .

Others, DNA/RNA Synthesis, Antibacterial, Topoisomerase

Microbiology/Virology, DNA Damage/DNA Repair, Cell Cycle/Checkpoint, Others

178128

C33H30O17

698.586

CO[C@@H]1C[C@H](O[C@@H]2c3c(O[C@@]22Oc4c(C[C@H]2O)cc2cc(oc(=O)c2c4O)C(=O)OC)c(O)c2C(=O)C(OC)=CC(=O)c2c3O)O[C@@H](C)[C@@H]1O |c:42|

-20°C

Ice Packs

Small Compound