Hellebrigenin - CAS 465-90-7

Hellebrigenin, as a selective inhibitor of MAPK signaling pathways (ERK, p38, JNK) and XIAP, effectively suppresses Akt expression and phosphorylation. This compound activates endogenous apoptosis pathways (including mitochondrial membrane potential disruption, Caspase family activation, and PARP cleavage) while modulating apoptosis-related protein expression. Hellebrigenin also induces DNA double-strand breaks to activate the ATM pathway, inhibiting tumor cell proliferation and clonogenesis, primarily applied in research of oral squamous cell carcinoma and liver cancer.

ERK, JNK, Apoptosis, p38 MAPK, PARP, Caspase, IAP

Proteases/Proteasome, Apoptosis, MAPK, DNA Damage/DNA Repair, Chromatin/Epigenetic

368

0.9998

C24H32O6

416.51

C(=O)[C@@]12[C@@]3([C@]([C@]4(O)[C@](C)(CC3)[C@H](CC4)C=5C=CC(=O)OC5)(CC[C@]1(O)C[C@@H](O)CC2)[H])[H]

-20°C

Ice Packs

Natural Product