HEMTAC CDK4/6 degrader 1 - CAS 2821803-61-4

HEMTAC CDK4/6 degrader 1 is a PROTAC connected by ligands for HSP90 and CDK4/6 with a \ (K_d \) value of 35.7 μM. It induces CDK4/6 degradation in B16F10 melanoma cells, arrests the cell cycle at the G0/G1 phase, and induces apoptosis. HEMTAC CDK4/6 degrader 1 can be used in cancer research [1].

Others, PROTACs, Apoptosis, CDK

Apoptosis, Others, Cell Cycle/Checkpoint, PROTAC

2821738

C48H53ClN16O4

953.49

O=C1N(C=2C(C(C)=C1C(C)=O)=CN=C(NC3=CC=C(C=N3)N4CCN(CC(NCC5=CN(CCC#CC=6C=7C(N(CC8=C(C)C(OC)=C(C)C=N8)C6)=NC(N)=NC7Cl)N=N5)=O)CC4)N2)C9CCCC9

-20°C

Ice Packs

PROTAC