Henatinib - CAS 1239269-51-2

Henatinib is an orally active small molecule multi-kinase inhibitor with broad antitumour effects. henatinib inhibits the activity of VEGFR-2 (IC50: 0.6 nM), c-kit (IC50: 3.3 nM), PDGFR (IC50: 41.5 nM) . henatinib significantly inhibits VEGFR-2 phosphorylation and its downstream signalling pathways in human umbilical vein endothelial cells (HUVECs) . Henatinib significantly inhibited VEGFR-2 phosphorylation and its downstream signaling pathway in human umbilical vein endothelial cells (HUVECs) .

PDGFR, c-Kit, Others, VEGFR

Others, Tyrosine Kinase/Adaptors, Angiogenesis

1239216

C25H29FN4O4

468.52

C(=C\1/C=2C(NC1=O)=CC=C(F)C2)\C3=C(C)C4=C(N3)CCCN(C[C@@H](CN5CCOCC5)O)C4=O

-20°C

Ice Packs

Small Compound